Chi Chun Wong Selected Research

Squalene Monooxygenase (Squalene Epoxidase)

11/2022	Squalene epoxidase drives cancer cell proliferation and promotes gut dysbiosis to accelerate colorectal carcinogenesis.
1/2021	Squalene Epoxidase Induces Nonalcoholic Steatohepatitis Via Binding to Carbonic Anhydrase III and is a Therapeutic Target.
1/2018	Squalene epoxidase drives NAFLD-induced hepatocellular carcinoma and is a pharmaceutical target.

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Chi Chun Wong Research Topics

Disease

26	Neoplasms (Cancer) 11/2022 - 05/2008
12	Colorectal Neoplasms (Colorectal Cancer) 01/2022 - 11/2016
9	Carcinogenesis 11/2022 - 01/2018
9	Stomach Neoplasms (Stomach Cancer) 01/2021 - 01/2016
4	Neoplasm Metastasis (Metastasis) 01/2022 - 01/2017
2	Fatty Liver 01/2022 - 01/2021
2	Colonic Neoplasms (Colon Cancer) 12/2021 - 01/2017
2	Non-alcoholic Fatty Liver Disease 01/2021 - 01/2018
1	Dysbiosis 11/2022
1	Liver Cirrhosis (Hepatic Cirrhosis) 12/2021
1	Fibrosis (Cirrhosis) 12/2021
1	Leukemia 12/2021
1	Disease Progression 01/2021
1	Gastrointestinal Neoplasms (Gastrointestinal Cancer) 01/2019
1	Metaplasia 01/2019
1	Hepatocellular Carcinoma (Hepatoma) 01/2018
1	Supernumerary Tooth (Supernumerary Teeth) 06/2009
1	Mitochondrial Diseases (Mitochondrial Disease) 05/2008

Drug/Important Bio-Agent (IBA)

8	Proteins (Proteins, Gene)FDA Link 12/2021 - 05/2008
6	Biomarkers (Surrogate Marker)IBA 11/2021 - 01/2017
6	Pharmaceutical PreparationsIBA 01/2021 - 05/2008
4	Messenger RNA (mRNA)IBA 12/2021 - 11/2016
4	CateninsIBA 12/2021 - 01/2018
4	MicroRNAs (MicroRNA)IBA 01/2021 - 11/2017
3	Squalene Monooxygenase (Squalene Epoxidase)IBA 11/2022 - 01/2018
3	CholesterolIBA 01/2022 - 01/2021
3	Fluorouracil (Carac)FDA LinkGeneric 12/2021 - 01/2016
2	Transcription Factors (Transcription Factor)IBA 03/2021 - 01/2021
2	RNA (Ribonucleic Acid)IBA 01/2021 - 01/2018
2	AzoxymethaneIBA 01/2020 - 01/2019
2	Biological ProductsIBA 01/2020 - 01/2018
2	DNA (Deoxyribonucleic Acid)IBA 01/2019 - 01/2019
1	Bile Acids and Salts (Bile Acids)IBA 11/2022
1	N-methyladenosineIBA 01/2022
1	RNA-Binding Proteins (RNA-Binding Protein)IBA 01/2022
1	Interleukin-12 (IL 12)IBA 01/2022
1	Small Interfering RNA (siRNA)IBA 01/2022
1	6-methyladenineIBA 01/2022
1	InterferonsIBA 01/2022
1	CytokinesIBA 01/2022
1	Choline (Choline Chloride)IBA 12/2021
1	Methionine (L-Methionine)FDA Link 12/2021
1	Ribosomal RNAIBA 12/2021
1	pladienolide BIBA 11/2021
1	A-factor (Streptomyces)IBA 10/2021
1	Carbonic Anhydrase IIIIBA 01/2021
1	dabrafenibIBA 01/2021
1	Notch ReceptorsIBA 01/2021
1	Phosphotransferases (Kinase)IBA 01/2021
1	Fibroblast Growth Factor Receptors (Fibroblast Growth Factor Receptor)IBA 10/2020
1	IonsIBA 09/2020
1	Carboxylic AcidsIBA 09/2020
1	EnzymesIBA 01/2020
1	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 01/2020
1	dimemorfan (AT 17)IBA 01/2020
1	Matrix Metalloproteinases (MMPs)IBA 01/2020
1	Dinoprostone (PGE2)FDA Link 01/2019
1	CytosineIBA 01/2019
1	EicosanoidsIBA 01/2019
1	Insulin-Like Growth Factor Binding Protein 5IBA 01/2019
1	rofecoxib (Vioxx)FDA Link 01/2019
1	Cyclooxygenase 2 Inhibitors (COX-2 Inhibitors)IBA 01/2019
1	Calcium-Binding ProteinsIBA 12/2018
1	Metformin (Glucophage)FDA LinkGeneric 12/2018
1	Terbinafine (Lamisil)FDA LinkGeneric 01/2018
1	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 01/2018
1	Cholesterol Esters (Cholesteryl Esters)IBA 01/2018
1	IsotopesIBA 01/2017
1	Glutamine (L-Glutamine)FDA Link 01/2017
1	Transcription Factor CHOPIBA 01/2017
1	Amino Acids FDA Link 01/2017
1	TunicamycinIBA 01/2017
1	Endoplasmic Reticulum Chaperone BiPIBA 01/2017
1	Sodium Channels (Sodium Channel)IBA 01/2017
1	Aspartic Acid (Aspartate)FDA Link 11/2016
1	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2016
1	MK 2206IBA 01/2016
1	2- amino- 1- methyl- 6- phenylimidazo(4,5- b)pyridineIBA 06/2009
1	Phenylalanine (L-Phenylalanine)FDA Link 06/2009
1	phenylacetaldehydeIBA 06/2009
1	indioside DIBA 05/2008
1	furostanol glycosideIBA 05/2008

Therapy/Procedure

3	Therapeutics 11/2021 - 01/2018
2	Drug Therapy (Chemotherapy) 12/2021 - 01/2019
1	Intraperitoneal Injections 12/2021